Friday, November 30, 2012

Aspirin link, in order to reduce the risk of liver cancer

The new study found that aspirin and other nonsteroidal anti-inflammatory drugs or non-steroidal anti-inflammatory drugs may help prevent serious liver disease, including cancer.

Aspirin users were 41 percent less likely to develop liver cancer, 45 percent less likely to die from chronic liver disease than non-users, according to the study of Vikrant Sahasrabuddhe, Rockville, Maryland, USA, United States National Cancer Research by and his colleagues.

Also lower the risk of death from chronic liver disease and other non-steroidal anti-inflammatory drugs, but less with liver cancer, the study of more than 300,000 middle-aged and older people.

"These associations highlight the use of aspirin, if confirmed, may open up new prospects for the chemoprevention of liver cancer and chronic liver disease wrote," in the magazine published by the U.S. National Cancer Institute on December 5.

The results showed that in colorectal cancer and other cancer types, past performance is not surprising, oncologist at the University of Alabama at Birmingham, Dr. Boris Pasche, MedPage Today in an interview with reporters, said .

"We are seeing more and more evidence that long-term use of aspirin can prevent the crowd of several types of NSAID use in the prevention of cardiovascular events in cancer development, he said.

However, in addition to myocardial protection is a possible additional benefits that aspirin may be necessary and beneficial to the protection of the liver, according to other experts.

For one thing, it has been a good strategy, do not increase the risk of bleeding in the way of non-steroidal anti-inflammatory drugs, Dr. Isra Levy and Carolyn Pim, University in Ontario, Ottawa, Ottawa Public Health, in pointed out in an editorial.

"In practice," they wrote, "We know and understand the reasons, in most cases, chronic liver disease and primary liver cancer virus infection, hepatitis B virus (HBV) and hepatitis C virus (HCV ), and alcohol. inexpensive, easy to use interventions to prevent most of these diseases. "

In addition, the risk of developing liver cancer is low enough chemoprevention in the general population is no sense to weigh the risk of bleeding, Dr. Marian said liver disease yellow at Henry Ford Hospital in Detroit.

Higher risk populations, for whom, prevention strategies need - cirrhosis - may not be a good candidate, because they are at a higher risk of bleeding, Huang told MedPage Today in an interview with reporters.

U.S. National Institutes of Health, the findings of the American Association of Retired Persons may be good enough prospective study to see whether the benefits outweigh the risks, the population, "Pasche recommendations.

A combination of diet and health study included 300,504 adults aged 50-71 years enrollment report their NSAID use baseline questionnaire.

Queue from six states (California, Florida, Louisiana, New Jersey, North Carolina and Pennsylvania) and two metropolitan areas (Atlanta and Detroit). Respondents, 73% of the respondents use aspirin, 56% of people use other non-steroidal anti-inflammatory drugs.

Aspirin effect is independent of the frequency of use.

All results were adjusted for age, gender, race or ethnicity, body mass index, smoking, alcohol consumption and diabetes.

The researchers suggested that the queue NSAID use anti-inflammatory or other mechanisms may be due to the obvious advantages.

However, they admit that the lack of a dose response found only monthly non-aspirin NSAID use "display the results should be interpreted with considerable caution, because they may also reflect unmeasured confounders.

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